Frances Thompson may refer to:
- Frances Thompson (died 1876), transgender former slave and anti-rape activist
- Frances Thompson, fictional character in 1993 TV drama Family of Strangers
- Frances Euphemia Thompson (1896–1992), African American artist and art educator
- Frances McBroom Thompson (1942–2014), American mathematician
- Mary Frances Thompson (1895–1995), native American storyteller
- Frances Willson Thompson, namesake of a library at the University of Michigan–Flint
See also
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