Extracellular matrix protein FRAS1 is a protein that in humans is encoded by the FRAS1 (Fraser syndrome 1) gene.[5][6] This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development.

FRAS1
Identifiers
AliasesFRAS1, Fraser extracellular matrix complex subunit 1, FRASRS1
External IDsOMIM: 607830; MGI: 2385368; HomoloGene: 23516; GeneCards: FRAS1; OMA:FRAS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166133
NM_020875
NM_025074
NM_032863
NM_206841

NM_175473

RefSeq (protein)

NP_001159605
NP_079350

NP_780682

Location (UCSC)Chr 4: 78.06 – 78.54 MbChr 5: 96.52 – 96.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Metastatic prostate cancer

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A single nucleotide switch (polymorphism) in FRAS1 promoter region is associated with metastatic Prostate cancer. The promoter region is directly related to the NFkB pathway and has been shown to be associated with lethal prostate cancer. [7]

Fras1 related extracellular matrix (FREM1[8]) directly relates to congenital diaphragmatic hernia in developing fetuses. Decreased expression of FREM1 may be linked with disruptions in the growth of diaphragm cells. Both FRAS1 and FREM1 are among the proteins that are primarily interacting during embryonic development. It is shown that a decrease in these two proteins lead to an increase of congenital diaphragmatic hernia in both humans and mice.[9]

Clinical significance

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Mutations in this gene have been observed to cause fraser syndrome.[10]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138759Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034687Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Fraser syndrome 1".
  6. ^ McGregor L, Makela V, Darling SM, Vrontou S, Chalepakis G, Roberts C, et al. (June 2003). "Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein". Nature Genetics. 34 (2): 203–208. doi:10.1038/ng1142. PMID 12766769. S2CID 1018128.
  7. ^ Wang V, Geybels MS, Jordahl KM, Gerke T, Hamid A, Penney KL, et al. (July 2021). "A polymorphism in the promoter of FRAS1 is a candidate SNP associated with metastatic prostate cancer". The Prostate. 81 (10): 683–693. doi:10.1002/pros.24148. PMC 8491321. PMID 33956343.
  8. ^ Li, Chumei; Slavotinek, Anne (1993), Adam, Margaret P.; Ardinger, Holly H.; Pagon, Roberta A.; Wallace, Stephanie E. (eds.), "FREM1 Autosomal Recessive Disorders", GeneReviews®, Seattle (WA): University of Washington, Seattle, PMID 20301721, retrieved 2021-11-23
  9. ^ Wang V, Geybels MS, Jordahl KM, Gerke T, Hamid A, Penney KL, et al. (July 2021). "A polymorphism in the promoter of FRAS1 is a candidate SNP associated with metastatic prostate cancer". The Prostate. 81 (10): 683–693. doi:10.1002/pros.24148. PMC 8491321. PMID 33956343.
  10. ^ "Fraser syndrome 1". February 23, 2010. Retrieved May 17, 2010.

Further reading

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