FOXK2

Forkhead box protein K2 is a protein that in humans is encoded by the FOXK2 gene.

FOXK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JXS, 2C6Y
Identifiers
Aliases	FOXK2, ILF, ILF-1, ILF1, forkhead box K2, nGTBP
External IDs	OMIM: 147685; MGI: 1916087; HomoloGene: 18748; GeneCards: FOXK2; OMA:FOXK2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.3 Start 82,519,713 bp End 82,644,662 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 121,259,990 bp End 121,309,896 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle sural nerve ganglionic eminence oocyte muscle of thigh ventricular zone left testis right testis gingival epithelium sperm Top expressed in zygote secondary oocyte cumulus cell ventricular zone ascending aorta renal corpuscle tail of embryo otic vesicle mandibular prominence spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding magnesium ion binding metal ion binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription cis-regulatory region binding DNA-binding transcription repressor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytoplasm Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription, DNA-templated transcription by RNA polymerase II protein deubiquitination anatomical structure morphogenesis cell differentiation negative regulation of transcription by RNA polymerase II cellular glucose homeostasis negative regulation of autophagy regulation of glucose metabolic process response to starvation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated canonical glycolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3607 68837 Ensembl ENSG00000141568 ENSMUSG00000039275 UniProt Q01167 Q3UCQ1 RefSeq (mRNA) NM_004514 NM_181430 NM_181431 NM_001080932 NM_001363033 RefSeq (protein) NP_004505 NP_001074401 NP_001349962 Location (UCSC) Chr 17: 82.52 – 82.64 Mb Chr 11: 121.26 – 121.31 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements.

Further reading

• Li C, Lusis AJ, Sparkes R, et al. (1992). "Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein ILF". Genomics. 13 (3): 665–71. doi:10.1016/0888-7543(92)90139-J. PMID 1339390.
• Li C, Lai CF, Sigman DS, Gaynor RB (1991). "Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7739–43. Bibcode:1991PNAS...88.7739L. doi:10.1073/pnas.88.17.7739. PMC 52378. PMID 1909027.
• Nirula A, Moore DJ, Gaynor RB (1997). "Constitutive binding of the transcription factor interleukin-2 (IL-2) enhancer binding factor to the IL-2 promoter". J. Biol. Chem. 272 (12): 7736–45. doi:10.1074/jbc.272.12.7736. PMID 9065434.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Liu PP, Chen YC, Li C, et al. (2003). "Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a)". Proteins. 49 (4): 543–53. doi:10.1002/prot.10227. PMID 12402362. S2CID 1142924.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Tsai KL, Huang CY, Chang CH, et al. (2006). "Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins". J. Biol. Chem. 281 (25): 17400–9. doi:10.1074/jbc.M600478200. PMID 16624804.
• Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature. 440 (7087): 1045–9. Bibcode:2006Natur.440.1045Z. doi:10.1038/nature04689. PMC 2610434. PMID 16625196.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

External links

• FOXK2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q01167 (Forkhead box protein K2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.