Fasciculation and elongation protein zeta-2 is a protein that in humans is encoded by the FEZ2 gene.[5][6]

FEZ2
Identifiers
AliasesFEZ2, HUM3CL, fasciculation and elongation protein zeta 2
External IDsOMIM: 604826; MGI: 2675856; HomoloGene: 3742; GeneCards: FEZ2; OMA:FEZ2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042548
NM_005102

NM_001285940
NM_001285946
NM_001285949
NM_199448
NM_001360407

RefSeq (protein)

NP_001036013
NP_005093

NP_001272869
NP_001272875
NP_001272878
NP_955519
NP_001347336

Location (UCSC)Chr 2: 36.53 – 36.65 MbChr 17: 78.68 – 78.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin.[6]

Interactions

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FEZ2 has been shown to interact with Protein kinase Mζ.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171055Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056121Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc Natl Acad Sci U S A. 94 (7): 3414–9. Bibcode:1997PNAS...94.3414B. doi:10.1073/pnas.94.7.3414. PMC 20384. PMID 9096408.
  6. ^ a b "Entrez Gene: FEZ2 fasciculation and elongation protein zeta 2 (zygin II)".
  7. ^ Fujita, Toshitsugu; Ikuta Junko; Hamada Juri; Okajima Toshihide; Tatematsu Kenji; Tanizawa Katsuyuki; Kuroda Shun'ichi (Jan 2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. 313 (3). United States: 738–44. doi:10.1016/j.bbrc.2003.12.006. ISSN 0006-291X. PMID 14697253.

Further reading

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