Euphrasius may refer to:
- Euphrasius of Illiturgis (fl. 1st century), Spanish Christian martyr, one of the Seven Apostolic Men
- Euphrasius (fl. 2nd century), Greek Christian martyr, one of the Seven Robbers
- Euphrasius (died c. 515), bishop of Clermont-Ferrand
- Euphrasius of Antioch (fl. 6th century), a Patriarch of Antioch 521–526
- Euphrasius (fl. 6th century), bishop of Poreč, namesake of the Euphrasian Basilica, Poreč, Croatia
- Euphrasius (bishop of Lugo) (died 688)
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