Equis may refer to:

  • EFMD Quality Improvement System (or EQUIS), an international system of assessment and accreditation of higher education institutions in management and business administration run by the European Foundation for Management Development
  • Equis International (or Equis) a Thomson Reuters software company which produces technical analysis software used in stock markets
  • Equis, album by Uruguayan rock band Snake
  • X, known as equis in the Spanish alphabet