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In Greek mythology, Epione (Greek: Ἠπιόνη) is the wife of Asclepius. Her name derives from the word ηπιος (epios, "soothing"), and she was probably a personification of the care needed for recovery. With Asclepius, she had two sons, Machaon and Podalirius, who are mentioned in the Iliad of Homer. The Suda lists Aceso, Aglaea, Hygieia, Iaso, and Panacaea as her daughters.
Epigraphical evidence suggests that Epione was a cultic figure in Athens, Epidauros, Kos, and Pergamon.