The enteric glia, enteric glial cells or EGCs are a population of neuroglial cells that populate the enteric nervous system.[1]
| Enteric glia | |
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| Anatomical terminology |
These cells are one of the major neural-crest-derived cell lineages, found throughout the gastrointestinal tract. The enteric glial cells play a variety of roles, such as modulating nociception (pain sensation), exerting immune functions, and coordingating gastrointestinal motility.[1][2][3] They are the largest glial population outside the brain, and considered "a key node of the gut-brain axis".[4]
References
edit- ^ a b Liu, Chang; Yang, Jing (2022-04-28). "Enteric Glial Cells in Immunological Disorders of the Gut". Frontiers in Cellular Neuroscience. 16. doi:10.3389/fncel.2022.895871. ISSN 1662-5102. PMC 9095930. PMID 35573829.
- ^ Morales-Soto, Wilmarie; Gonzales, Jacques; Jackson, William F.; Gulbransen, Brian D. (2023-11-21). "Enteric glia promote visceral hypersensitivity during inflammation through intercellular signaling with gut nociceptors". Science Signaling. 16 (812): eadg1668. doi:10.1126/scisignal.adg1668. ISSN 1945-0877. PMC 10733972. PMID 37988454.
- ^ Scavuzzo, Marissa A.; Letai, Katherine C.; Maeno-Hikichi, Yuka; Wulftange, William J.; Shah, Isha K.; Rameshbabu, Jeyashri S.; Tomar, Alka; Shick, H. Elizabeth; Shah, Aakash K.; Xiong, Ying; Cohn, Erin F.; Allan, Kevin C.; Tesar, Paul J. (2023-06-09). "Enteric glial hub cells coordinate intestinal motility". bioRxiv: 2023.06.07.544052. doi:10.1101/2023.06.07.544052. PMC 10274798. PMID 37333182.
- ^ Rosenberg, Harry J.; Rao, Meenakshi (August 2021). "Enteric glia in homeostasis and disease: From fundamental biology to human pathology". iScience. 24 (8): 102863. Bibcode:2021iSci...24j2863R. doi:10.1016/j.isci.2021.102863. ISSN 2589-0042. PMC 8348155. PMID 34401661.
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