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The river flows in a northwesterly direction at a total length of 180.6 km.
The Ene River is part of the headwaters of the Amazon River whose origin is at the Mismi south of Cuzco where it first becomes Apurímac River, then the Ene River and Tambo River before its waters meet the Ucayali River which later forms the Amazon.
The proposed 2,200-megawatt Pakitzapango hydroelectric dam would flood much of the Ene River valley. Protests by the Central Ashaninka del Rio Ene (CARE, Asháninka Center of the Ene River) and Ruth Buendia (president since 2005) have halted the construction. For her efforts Buendia was awarded the Goldman Environmental Prize in 2014.
- "Pakitzapango Dam". International Rivers. Retrieved April 30, 2016.
- Monti Aguirre (April 28, 2014). "Ruth Buendía of Peru Wins 2014 Goldman Environmental Prize". International Rivers. Retrieved April 30, 2016.
- "Prize Recipient: Ruth Buendia, 2014 South & Central America". Goldman Environmental Prize. Retrieved 3 June 2014.