Empress Guo may refer to:
- Guo Shengtong (6–52), wife of Emperor Guangwu of Han
- Guo Nüwang (184–235), wife of Emperor Wen of Cao Wei
- Empress Guo (Cao Rui's wife) (died 264), wife of Emperor Ming of Cao Wei
- Empress Dowager Guo (Tang dynasty) (died 848), wife of Emperor Xianzong of Tang
- Empress Guo (Zhenzong) (975–1007), wife of Emperor Zhenzong of Song
- Empress Guo (Renzong) (1012–1035), wife of Emperor Renzong of Song
- Empress Xiaoyuanzhen (1580–1613), wife of the Taichang Emperor
This disambiguation page lists articles associated with the title Empress Guo.
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