Ets variant 5 (ETV5) (also named ERM transcription factor) is a transcription factor that in humans is encoded by the ETV5 gene.[5] It is generated in Sertoli cells, which are found in the testes and play a crucial role in spermatogenesis. Its ortholog has been linked to both obesity and bipolar disorder.[6]

ETV5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesETV5, ERM, ETS variant 5, ETS variant transcription factor 5
External IDsOMIM: 601600; MGI: 1096867; HomoloGene: 3276; GeneCards: ETV5; OMA:ETV5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004454

NM_023794
NM_001358428

RefSeq (protein)

NP_004445

NP_076283
NP_001345357

Location (UCSC)Chr 3: 186.05 – 186.11 MbChr 16: 22.2 – 22.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
ets variant gene 5 (ets-related molecule)
Identifiers
SymbolETV5
Alt. symbolsERM
NCBI gene2119
HGNC3494
OMIM601600
RefSeqNM_004454
UniProtP41161
Other data
LocusChr. 3 q28
Search for
StructuresSwiss-model
DomainsInterPro

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000244405Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013089Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Ets variant 5".
  6. ^ Williams MJ, Klockars A, Eriksson A, Voisin S, Dnyansagar R, Wiemerslage L, Kasagiannis A, Akram M, Kheder S, Ambrosi V, Hallqvist E, Fredriksson R, Schiöth HB (June 2016). "The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder". PLOS Genetics. 12 (6): e1006104. doi:10.1371/journal.pgen.1006104. PMC 4900636. PMID 27280443.

Further reading

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