Ectonucleoside triphosphate diphosphohydrolase 5 is an enzyme that in humans is encoded by the ENTPD5 gene.[5][6][7]

ENTPD5
Identifiers
AliasesENTPD5, CD39L4, NTPDase-5, PCPH, ectonucleoside triphosphate diphosphohydrolase 5, ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
External IDsOMIM: 603162; MGI: 1321385; HomoloGene: 37457; GeneCards: ENTPD5; OMA:ENTPD5 - orthologs
EC number3.6.1.42
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001026214
NM_001286049
NM_001286058
NM_007647

RefSeq (protein)

NP_001021385
NP_001272978
NP_001272987
NP_031673

Location (UCSC)Chr 14: 73.96 – 74.02 MbChr 12: 84.42 – 84.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ENTPD5 is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187097Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021236Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chadwick BP, Frischauf AM (Oct 1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mamm Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.
  6. ^ Chadwick BP, Frischauf AM (Oct 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.
  7. ^ a b "Entrez Gene: ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5".

Further reading

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