ELAV-like protein 1 or HuR (human antigen R) is a protein that in humans is encoded by the ELAVL1 gene .[5] [6]
The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements . One of its best-known functions is to stabilize mRNAs in order to regulate gene expression.[7]
See also
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References
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^ a b c GRCh38: Ensembl release 89: ENSG00000066044 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040028 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ma WJ, Cheng S, Campbell C, et al. (Jun 1996). "Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein" . J Biol Chem . 271 (14): 8144–8151. doi :10.1074/jbc.271.14.8144 PMID 8626503 . ^ Ma WJ, Furneaux H (Feb 1997). "Localization of the human HuR gene to chromosome 19p13.2". Hum Genet . 99 (1): 32–33. doi :10.1007/s004390050305 . PMID 9003489 . S2CID 32509747 . ^ "Entrez Gene: ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)" .^ Brenda Janice Sánchez; Souad Mubaid; Sandrine Busque; et al. (22 February 2023). "The formation of HuR/YB1 complex is required for the stabilization of target mRNA to promote myogenesis" . Nucleic Acids Research . 51 (3): 1375–1392. doi :10.1093/nar/gkac1245 . hdl :10754/687126 PMC 9943665 PMID 36629268 .
Further reading
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Abdelmohsen K, Lal A, Kim HH, et al. (2007). "Posttranscriptional orchestration of an anti-apoptotic program by HuR" . Cell Cycle . 6 (11): 1288–92. doi :10.4161/cc.6.11.4299 PMID 17534146 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Sakai K, Kitagawa Y, Hirose G (1999). "Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA". Biochem. Biophys. Res. Commun . 256 (2): 263–268. doi :10.1006/bbrc.1999.0282 . PMID 10079173 . Wang W, Furneaux H, Cheng H, et al. (2000). "HuR regulates p21 mRNA stabilization by UV light" . Mol. Cell. Biol . 20 (3): 760–769. doi :10.1128/MCB.20.3.760-769.2000 . PMC 85192 PMID 10629032 . Blaxall BC, Pellett AC, Wu SC, et al. (2000). "Purification and characterization of beta-adrenergic receptor mRNA-binding proteins" . J. Biol. Chem . 275 (6): 4290–4297. doi :10.1074/jbc.275.6.4290 PMID 10660597 . Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA" . Mol. Cell. Biol . 20 (13): 4765–4772. doi :10.1128/MCB.20.13.4765-4772.2000 . PMC 85909 PMID 10848602 . Spångberg K, Wiklund L, Schwartz S (2000). "HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities" . Virology . 274 (2): 378–390. doi :10.1006/viro.2000.0461 PMID 10964780 . Brennan CM, Gallouzi IE, Steitz JA (2000). "Protein ligands to HuR modulate its interaction with target mRNAs in vivo" . J. Cell Biol . 151 (1): 1–14. doi :10.1083/jcb.151.1.1 . PMC 2189805 PMID 11018049 . Gallouzi IE, Steitz JA (2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides". Science . 294 (5548): 1895–1901. Bibcode :2001Sci...294.1895G . doi :10.1126/science.1064693 . PMID 11729309 . S2CID 43726887 . Goldberg-Cohen I, Furneauxb H, Levy AP (2002). "A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR" . J. Biol. Chem . 277 (16): 13635–13640. doi :10.1074/jbc.M108703200 PMID 11834731 . Wang W, Fan J, Yang X, et al. (2002). "AMP-activated kinase regulates cytoplasmic HuR" . Mol. Cell. Biol . 22 (10): 3425–3436. doi :10.1128/MCB.22.10.3425-3436.2002 . PMC 133799 PMID 11971974 . Yeap BB, Voon DC, Vivian JP, et al. (2002). "Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA" . J. Biol. Chem . 277 (30): 27183–27192. doi :10.1074/jbc.M202883200 PMID 12011088 . Li H, Park S, Kilburn B, et al. (2003). "Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase" . J. Biol. Chem . 277 (47): 44623–44630. doi :10.1074/jbc.M206187200 PMID 12237300 . Chen CY, Xu N, Shyu AB (2002). "Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization" . Mol. Cell. Biol . 22 (20): 7268–7278. doi :10.1128/MCB.22.20.7268-7278.2002 . PMC 139819 PMID 12242302 . Giles KM, Daly JM, Beveridge DJ, et al. (2003). "The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein" . J. Biol. Chem . 278 (5): 2937–2946. doi :10.1074/jbc.M208439200 PMID 12431987 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Wang W, Yang X, López de Silanes I, et al. (2003). "Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function" . J. Biol. Chem . 278 (29): 27016–27023. doi :10.1074/jbc.M300318200 PMID 12730239 .
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