Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene.[5][6][7][8] It belongs to the eukaryotic translation initiation factor 4E family.

EIF4E2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF4E2, 4E-LP, 4EHP, EIF4EL3, IF4e, eukaryotic translation initiation factor 4E family member 2, h4EHP
External IDsOMIM: 605895; MGI: 1914440; HomoloGene: 128466; GeneCards: EIF4E2; OMA:EIF4E2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001039169
NM_001039170
NM_023314
NM_001347083

RefSeq (protein)

NP_001034258
NP_001034259
NP_001334012
NP_075803

Location (UCSC)Chr 2: 232.55 – 232.58 MbChr 1: 87.14 – 87.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

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EIF4E2 has been shown to interact with ARIH1.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135930Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026254Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, et al. (July 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–8180. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
  6. ^ Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, Olsen H, et al. (May 1998). "Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein". The Journal of Biological Chemistry. 273 (21): 13104–13109. doi:10.1074/jbc.273.21.13104. PMID 9582349.
  7. ^ "Entrez Gene: EIF4E2 eukaryotic translation initiation factor 4E family member 2".
  8. ^ Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, et al. (September 2012). "A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development". Molecular and Cellular Biology. 32 (17): 3585–3593. doi:10.1128/MCB.00455-12. PMC 3422012. PMID 22751931.
  9. ^ Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (November 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Letters. 554 (3): 501–504. doi:10.1016/S0014-5793(03)01235-3. PMID 14623119. S2CID 25441190.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: O60573 (Eukaryotic translation initiation factor 4E type 2) at the PDBe-KB.