Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P4.[5]

S1PR4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesS1PR4, EDG6, LPC1, S1P4, SLP4, sphingosine-1-phosphate receptor 4
External IDsOMIM: 603751; MGI: 1333809; HomoloGene: 2799; GeneCards: S1PR4; OMA:S1PR4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003775

NM_010102

RefSeq (protein)

NP_003766

NP_034232

Location (UCSC)Chr 19: 3.17 – 3.18 MbChr 10: 81.33 – 81.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene is a member of the endothelial differentiation, G-protein-coupled (EDG) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.[5]

Evolution

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See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125910Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044199Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: S1PR4 Sphingosine-1-phosphate receptor 4".
  6. ^ "Ensembl Genome Browser".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.