E68 may refer to:
- European route E68, a road
- A Fianchetto variation of the King's Indian Defence, Encyclopaedia of Chess Openings code
- Chūō Expressway Kawaguchiko Route and Higashifuji-goko Road, route E68 in Japan
- Estrella Sailport, a privately-owned public use airport in the U.S.A.
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