E-55888

E-55888
Identifiers
	IUPAC name N,N-dimethyl-3-(1,3,5-trimethyl-1H-pyrazol-4-yl)phenethylamine;
CAS Number	1034142-33-0;
PubChem CID	24825775;
IUPHAR/BPS	3929;
ChemSpider	34980845;
UNII	4KQ7F7PL4L;
ChEMBL	ChEMBL4205349;
CompTox Dashboard (EPA)	DTXSID901029789 ;
Chemical and physical data
Formula	C16H23N3
Molar mass	257.381 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cn1nc(C)c(c1C)-c(c2)cccc2CCN(C)C;
	InChI InChI=1S/C16H23N3/c1-12-16(13(2)19(5)17-12)15-8-6-7-14(11-15)9-10-18(3)4/h6-8,11H,9-10H2,1-5H3; Key:MFUWRMRKXKCSPL-UHFFFAOYSA-N;
	(verify)

E-55888 is a drug developed by Esteve, which acts as a potent and selective full agonist at the 5HT₇ serotonin receptor, and is used for investigating the role of 5-HT₇ receptors in the perception of pain. When administered by itself, E-55888 is anti-hyperalgesic but not analgesic, but when administered alongside morphine, E-55888 was found to significantly increase the analgesic effects.^[1]^[2]

References

^ Brenchat A, Romero L, García M, Pujol M, Burgueño J, Torrens A, Hamon M, Baeyens JM, Buschmann H, Zamanillo D, Vela JM (February 2009). "5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice". Pain. 141 (3): 239–47. doi:10.1016/j.pain.2008.11.009. PMID 19118950. S2CID 27144262.
^ Brenchat A, Ejarque M, Zamanillo D, Vela JM, Romero L (August 2011). "Potentiation of Morphine Analgesia by Adjuvant Activation of 5-HT(7) Receptors". Journal of Pharmacological Sciences. 116 (4): 388–91. doi:10.1254/jphs.11039sc. PMID 21778664.

[pmid19118950-1] Brenchat A, Romero L, García M, Pujol M, Burgueño J, Torrens A, Hamon M, Baeyens JM, Buschmann H, Zamanillo D, Vela JM (February 2009). "5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice". Pain. 141 (3): 239–47. doi:10.1016/j.pain.2008.11.009. PMID 19118950. S2CID 27144262.

[pmid21778664-2] Brenchat A, Ejarque M, Zamanillo D, Vela JM, Romero L (August 2011). "Potentiation of Morphine Analgesia by Adjuvant Activation of 5-HT(7) Receptors". Journal of Pharmacological Sciences. 116 (4): 388–91. doi:10.1254/jphs.11039sc. PMID 21778664.

[1]

[2]

Identifiers

IUPAC name N,N-dimethyl-3-(1,3,5-trimethyl-1H-pyrazol-4-yl)phenethylamine
CAS Number	1034142-33-0
PubChem CID	24825775
IUPHAR/BPS	3929
ChemSpider	34980845
UNII	4KQ7F7PL4L
ChEMBL	ChEMBL4205349
CompTox Dashboard (EPA)	DTXSID901029789
Chemical and physical data
Formula	C₁₆H₂₃N₃
Molar mass	257.381 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Cn1nc(C)c(c1C)-c(c2)cccc2CCN(C)C
InChI InChI=1S/C16H23N3/c1-12-16(13(2)19(5)17-12)15-8-6-7-14(11-15)9-10-18(3)4/h6-8,11H,9-10H2,1-5H3 Key:MFUWRMRKXKCSPL-UHFFFAOYSA-N
(verify)

E-55888

See also

References