Duquesnoy is a surname, and may refer to:
- Adrien Duquesnoy (1759–1808), French political figure during the French Revolution
- Ernest Dominique François Joseph Duquesnoy (1749–1795), Radical French political figure during the French Revolution and brother of Florent Joseph Duquesnoy
- Florent Joseph Duquesnoy (1761–1801), French general during the French Revolution and brother of Ernest Dominique François Joseph Duquesnoy
- François Duquesnoy (1597–1643), Flemish sculptor of the Baroque period
- Jerôme Duquesnoy (II) (1602–1654), Flemish architect and sculptor of the Baroque period
- Tom Duquesnoy (born 1993), French mixed martial artist