• Comment: I'm not seeing evidence this is real. If you could provide quotes from these sources that verify the content, I think we could move forward. Pbritti (talk) 04:39, 19 December 2023 (UTC)

Introduction

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Sunny syndrome (Severe Untreatable Non-transmitted Neoplastic Yokel Syndrome) is a severe syndrome complicated with a variety of other either infectious or congenital (Mostly genetic) diseases, e.g. HIV, syphilis, Down's syndrome, etc. This disease is currently found to be untreatable, mostly because of its deep genetic root.[1] and multiple complications. Rather than being a specific disease, sunny syndrome more resembles a combination of various diseases.

However, Sunny syndrome is not a confirmed syndrome till now (19, Dec, 2023 edited). Almost no related literature can be found. Therefore, we desperately hope that medical advancement in this field can be made in the near future.

Diagnosis

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Clinical diagnosis

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Sunny syndrome can be suspected if three of the following symptoms are presented:

  1. Aphasia
  2. Motor disability
  3. Intellectual disability, mentally retarded (Mostly associated with Down's syndrome[2]). Notice that some sunny syndrome patients may not manifest intellectual symptoms or no mild retardation.
  4. High stature
  5. Inappropriate laughter (Associated with Angelman syndrome[3])
  6. Recurrent infection (Mostly Staphylococcus Aureus and Influenza virus.). Systemic manifestations, e.g. fever, malaise, headache, sore throat, etc. are presented with the infection[4]

Karyotypic diagnosis

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Karyotypic diagnosis is based the complicated diseases, such as Down's syndrome (aneuploid, translocated or mosaic trisomy 21).

Clinical manifestation

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Clinical manifestation correlates with the clinical diagnosis.

Treatment

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There is currently no treatment to this syndrome. Mostly because of its deep genetic root.[1]

Reference

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  1. ^ a b Agarwal Gupta, Neerja; Kabra, Madhulika (June 2014). "Diagnosis and management of Down syndrome". Indian Journal of Pediatrics. 81 (6): 560–567. doi:10.1007/s12098-013-1249-7. ISSN 0973-7693. PMID 24127006. S2CID 28986865.
  2. ^ Mazurek, Dominika; Wyka, Joanna (2015). "Down syndrome--genetic and nutritional aspects of accompanying disorders". Roczniki Panstwowego Zakladu Higieny. 66 (3): 189–194. ISSN 0035-7715. PMID 26400113.
  3. ^ Samanta, Debopam (January 2021). "Epilepsy in Angelman syndrome: A scoping review". Brain & Development. 43 (1): 32–44. doi:10.1016/j.braindev.2020.08.014. ISSN 1872-7131. PMC 7688500. PMID 32893075.
  4. ^ Ladhani, Husayn A.; Yowler, Charles J.; Claridge, Jeffrey A. (February 2021). "Burn Wound Colonization, Infection, and Sepsis". Surgical Infections. 22 (1): 44–48. doi:10.1089/sur.2020.346. ISSN 1557-8674. PMID 33085576. S2CID 224828652.