Draft:CT-996

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Instructions · What links here · CT-996 (talk: + · bio) · (log) · Copyvios report · reFill · Citation Bot · (Search: Google, Bing, Wikipedia) · Submitted 3 seconds ago by Catalizator (talk: D · +) · Last edited 3 seconds ago by Catalizator

CT-996 is an once daily oral small molecule GLP-1 agonist developed to treat obesity and type 2 diabetes.^[1] It is designed with minimal-to-no beta-arrestin recruitment.^[2] In a double-blind, randomized, placebo-controlled Phase I clinical trial participants averaged 6.1 percent placebo adjusted weight loss within four weeks.^[3]^[4]^[5]^[6] The drug is being developed by Roche/Genentech after Roche's takeover of Carmot Therapeutics in January 2024.^[7]^[8]

References

^ owenhaskins (2023-10-12). "Carmot's CT-996 GLP-1 candidate supports once-daily oral dosing for obesity and type 2 diabetes". Bariatric News. Retrieved 2024-07-28.
^ "Clinical Trials | Carmot Therapeutics | Drug Discovery and Development". Carmot Therapeutics. Retrieved 2024-07-26.
^ "Roche - Press release, July 17, 2024". www.roche.com. Retrieved 2024-07-26.
^ "CT-996 Demonstrates Significant Weight Loss in Patients with Obesity and Type 2 Diabetes". PharmExec. 2024-07-18. Retrieved 2024-07-26.
^ "ClinicalTrials.gov". clinicaltrials.gov. Retrieved 2024-07-28.
^ "Handelsblatt". www.handelsblatt.com (in German). Retrieved 2024-07-28.
^ Brody, Micaela (2024-01-29). "Carmot Therapeutics Announces Completion of Acquisition by Roche | Carmot Therapeutics | Drug Discovery and Development". Carmot Therapeutics. Retrieved 2024-07-26.
^ Burger, Ludwig (December 4, 2023). "Roche joins race for obesity drugs with $2.7 billion Carmot deal". Reuters. Retrieved July 28, 2024.

[1] wenhaskins (2023-10-12). "Carmot's CT-996 GLP-1 candidate supports once-daily oral dosing for obesity and type 2 diabetes". Bariatric News. Retrieved 2024-07-28.

[2] "Clinical Trials | Carmot Therapeutics | Drug Discovery and Development". Carmot Therapeutics. Retrieved 2024-07-26.

[3] "Roche - Press release, July 17, 2024". www.roche.com. Retrieved 2024-07-26.

[4] "CT-996 Demonstrates Significant Weight Loss in Patients with Obesity and Type 2 Diabetes". PharmExec. 2024-07-18. Retrieved 2024-07-26.

[5] "ClinicalTrials.gov". clinicaltrials.gov. Retrieved 2024-07-28.

[6] "Handelsblatt". www.handelsblatt.com (in German). Retrieved 2024-07-28.

[7] Brody, Micaela (2024-01-29). "Carmot Therapeutics Announces Completion of Acquisition by Roche | Carmot Therapeutics | Drug Discovery and Development". Carmot Therapeutics. Retrieved 2024-07-26.

[8] Burger, Ludwig (December 4, 2023). "Roche joins race for obesity drugs with $2.7 billion Carmot deal". Reuters. Retrieved July 28, 2024.

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