Wikipedia

Draft:Alimetry Limited


Alimetry Limited
FoundersProf. Gregory O'Grady Dr. Armen Gharibans
IndustryHealthcare Devices
HeadquartersAuckland, New Zealand
RegionGlobal
Founded on14 May 2019
Websitewww.alimetry.com

Alimetry Limited is a medical device company that designs, manufactures, and distributes wearable digital health products that aid in the diagnosis of gastric disorders. The company's first product is called Gastric Alimetry.[1]

History

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Alimetry Limited was established in 2019 by Professor Gregory O'Grady and Dr. Armen Gharibans, as a spin-off from the University of Auckland. [1][2] Alimetry was founded on research in gastrointestinal electrophysiology, and the company has won awards including the Excellence in Innovation Award at the New Zealand International Business Awards[3], Most Innovative Hi-Tech Hardware Product, Most Innovative Hi-Tech Creative Technology Solution, and Most Innovative Deep Tech Solution at the New Zealand Hi-Tech Awards.[4] The company focuses on the non-invasive assessment of electrophysiology, motility patterns, and symptom profiles in patients with chronic gastrointestinal symptoms[1][5].

Products

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Gastric Alimetry

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The Gastric Alimetry System is a medical device to aid in the diagnosis of various gastric disorders[6]. The system incorporates a wearable device employing body surface gastric mapping technology derived from Electrogastrogram research. It captures electrophysioloigcal data from the stomach alongside patient-reported symptoms, including nausea, vomiting, abdominal pain, and bloating[2][7].

Technology

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The Gastric Alimetry device employs patented body surface gastric mapping technology, utilizing a sensor array and connector to detect electrophysiological data from the stomach.[7] Validated in both a porcine animal model[8], and human participants, [7][9] this technology has demonstrated it can accurately assess gastric function non-invasively.

Clinical Research

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Some key evidence papers include:

  • Gastric dysfunction in patients with chronic nausea and vomiting syndromes defined by a noninvasive gastric mapping device (2022)[9]
    • This study mapped 43 patients with chronic nausea and vomiting syndromes with 43 matched controls. The results validated the Gastric Alimetry technology in patients with chronic nausea and vomiting by showing that abnormalities could be detected by the device. Two subtypes of nausea and vomiting symptoms with indistinguishable symptoms could be detected.
  • Normative Values for Body Surface Gastric Mapping Evaluations of Gastric Motility Using Gastric Alimetry: Spectral Analysis (2023)[10]
    • Normative reference intervals for key metrics of gastric motility were established in this paper. The metrics are; Principal Gastric Frequency, Gastric Alimetry Rhythm Index, BMI-adjusted amplitude, and Fed:Fasted Amplitude Ratio.
  • Comparison of Gastric Alimetry® body surface gastric mapping versus electrogastrography spectral analysis (2023)[11]
    • Gastric Alimetry was directly compared to electrogastrography in a cohort of 178 participants. Body surface gastric mapping was shown to perform substantially better than EGG across group-level differences, symptom correlations, and patient-level classifications.

Regulatory Approvals, Market, and Applications

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Gastric Alimetry holds regulatory approvals for use in the UK, New Zealand, and the USA, receiving FDA approval in 2022[1][6]. In 2022, Alimetry's US-based subsidiary called Alimetry Inc., was established and it is headquartered in Minneapolis, MN.[12] The company has obtained ISO13485 registration, ensuring compliance with international standards for medical device manufacturers[13].

Awards, Recognition, and Grants

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Alimetry was awarded the inaugural Ārohia Trailblazer Grant from Callaghan Innovation,[14] the Excellence in Innovation Award at the New Zealand International Business Awards 2023, and three awards at the New Zealand Hi-Tech Awards in 2022.[3][4] Alimetry was also a finalist in the the Asia Pacific MedTech Innovator competition, [15] and won the Medtronic APAC Innovation Challenge.[16] Additionally, Alimetry has been recognized for its design excellence, receiving awards at the Best Design Awards NZ[17][18] and the Good Design Awards Australia.[19]

Investors

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Alimetry secured its initial funding round in December 2020, followed by a Series A raise of NZ$16.3 million in March 2022[20]. The Series A round was led by Movac with support from existing investors such as UniServices, IP Group, Matū Karihi, and K1W1.[21]

References

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  1. ^ a b c d "Alimetry — decoding the gut". techweek.co.nz. Retrieved 2024-07-15.
  2. ^ a b theBit (2021-07-16). "Alimetry: The Auckland startup that wants to digitise your gut - theBit.nz". Retrieved 2024-07-15.
  3. ^ a b "Meet the winners of the New Zealand International Business Awards 2023". New Zealand Trade & Enterprise. 24 November 2023.
  4. ^ a b "2022 Hi-Tech Awards: Three gongs for Alimetry, McCrae honoured". NZ Herald. 2024-07-16. Retrieved 2024-07-15.
  5. ^ theBit (2021-07-16). "Alimetry: The Auckland startup that wants to digitise your gut - theBit.nz". Retrieved 2024-07-15.
  6. ^ a b "pdf (fda.gov)" (PDF). Food and Drug Administration.
  7. ^ a b c Gharibans, A. A.; Hayes TCL; Carson, D. A.; Calder, S.; Varghese, C.; Du, P.; Yarmut, Y.; Waite, S.; Keane, C.; Woodhead JST; Andrews, C. N.; O'Grady, G. (2023). "A novel scalable electrode array and system for non-invasively assessing gastric function using flexible electronics". Neurogastroenterology & Motility. 35 (2): e14418. doi:10.1111/nmo.14418. PMC 10078595. PMID 35699340.
  8. ^ Calder, Stefan; Cheng, Leo K.; Andrews, Christopher N.; Paskaranandavadivel, Niranchan; Waite, Stephen; Alighaleh, Saeed; Erickson, Jonathan C.; Gharibans, Armen; O’Grady, Gregory; Du, Peng (2022-10-01). "Validation of noninvasive body-surface gastric mapping for detecting gastric slow-wave spatiotemporal features by simultaneous serosal mapping in porcine". American Journal of Physiology-Gastrointestinal and Liver Physiology. 323 (4): G295–G305. doi:10.1152/ajpgi.00049.2022. ISSN 0193-1857. PMID 35916432.
  9. ^ a b Gharibans, Armen A.; Calder, Stefan; Varghese, Chris; Waite, Stephen; Schamberg, Gabriel; Daker, Charlotte; Du, Peng; Alighaleh, Saeed; Carson, Daniel; Woodhead, Jonathan; Farrugia, Gianrico; Windsor, John A.; Andrews, Christopher N.; O’Grady, Greg (2022-09-21). "Gastric dysfunction in patients with chronic nausea and vomiting syndromes defined by a noninvasive gastric mapping device". Science Translational Medicine. 14 (663): eabq3544. doi:10.1126/scitranslmed.abq3544. ISSN 1946-6234. PMC 10042458. PMID 36130019.
  10. ^ Varghese, Chris; Schamberg, Gabriel; Calder, Stefan; Waite, Stephen; Carson, Daniel; Foong, Daphne; Wang, William Jiaen; Ho, Vincent; Woodhead, Jonathan; Daker, Charlotte; Xu, William; Du, Peng; Abell, Thomas L.; Parkman, Henry P.; Tack, Jan (2023-06-01). "Normative Values for Body Surface Gastric Mapping Evaluations of Gastric Motility Using Gastric Alimetry: Spectral Analysis". The American Journal of Gastroenterology. 118 (6): 1047–1057. doi:10.14309/ajg.0000000000002077. ISSN 1572-0241. PMID 36534985.
  11. ^ Schamberg, Gabriel; Calder, Stefan; Varghese, Chris; Xu, William; Wang, William Jiaen; Ho, Vincent; Daker, Charlotte; Andrews, Christopher N.; O’Grady, Greg; Gharibans, Armen A. (2023-09-11). "Comparison of Gastric Alimetry® body surface gastric mapping versus electrogastrography spectral analysis". Scientific Reports. 13 (1): 14987. doi:10.1038/s41598-023-41645-w. ISSN 2045-2322. PMC 10495352. PMID 37696955.
  12. ^ "American Chamber of Commerce in New Zealand Inc - Alimetry receives FDA clearance for Gastric Alimetry". amcham.co.nz. Retrieved 2024-07-16.
  13. ^ "Registration Certificate". Alimetry. Retrieved 2024-07-16.
  14. ^ "First Ārohia Innovation Trailblazer Grant recipients". Callaghan Innovation. 2023-11-30. Retrieved 2024-07-16.
  15. ^ "MedTech Innovator Asia Pacific 2022 Finals Competition". MedTech Innovator. Retrieved 2024-07-16.
  16. ^ "Roundup: The Clinician, Alimetry win Medtronic APAC Innovation Challenge, NZHIT rebrands to Digital Health Association". Healthcare IT News. 2022-04-01. Retrieved 2024-07-16.
  17. ^ "Gastric Alimetry | Best Awards". bestawards.co.nz. Retrieved 2024-07-16.
  18. ^ "Alimetry | Best Awards". bestawards.co.nz. Retrieved 2024-07-16.
  19. ^ "Gastric Alimetry". Good Design. Retrieved 2024-07-16.
  20. ^ "Healthtech investors seek quality over quantity as capital remains tight | Caffeine | The daily for New Zealand's Startups". www.caffeinedaily.co. Retrieved 2024-07-16.
  21. ^ McMurchy, Lovina (2022-03-01). "Investment notes - Alimetry". Movac | Venture Capital. Retrieved 2024-07-16.
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