Don Gregorio may refer to:
- Don Gregorio, Dominican Republic, town in the Dominican Republic
- Don Gregorio (opera), by Donizetti, a revised version of L'ajo nell'imbarazzo
- Nickname
- Gregorio Pérez, Uruguayan football player and manager
- Gregorio Pérez Companc, richest person in Argentina
This disambiguation page lists articles associated with the title Don Gregorio.
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