Di Giovanni or De Giovanni is a surname. Notable people with the surname include:
- Bartolomeo di Giovanni (died 1501), early Renaissance Italian painter
- Benvenuto di Giovanni (c. 1436–1509/1518), Italian painter and artist
- Bertoldo di Giovanni (after 1420–1491), Italian sculptor and medallist
- Katya De Giovanni, Maltese politician
- Matteo di Giovanni (c. 1430–1495), Italian Renaissance artist