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Dennis T. Mangano (born September 2, 1943) is an American physician and mathematical physicist, known for his work in diffraction in compressible plasmas and algorithms for SONAR at Bell Laboratories. In medicine, Mangano's work highlighted the effectiveness of aspirin and beta-blocker therapy in preventing heart-related issues.[1] His research also revealed potential dangers, leading to the withdrawal of certain medical treatments.[2]
Career
editMangano is the founding director of the Multicenter Study of Perioperative Ischemia (McSPI) and The Ischemia Research and Education Foundation (IREF).[3] His mathematical research interests include plasma physics and statistical communication theory.[4] In the medical field, he focuses on aspirin and beta-blocker therapy, as well as drug safety concerning cox-2, anesthetic, and coagulation therapy.[5]
Mangano’s work on surgical therapeutics and drug safety includes:
- Demonstrating the effectiveness of Aspirin Therapy in preventing Heart Attack, Stroke, and Kidney Failure.[3][6]
- Establishing the effectiveness of Beta-Blocker Therapy on Mortality and Long-Term Survival.[7]
- Discovering the incidence/prevalence of Cardiac Reperfusion Injury.
- Highlighting the dangers of Coagulation Therapy on Heart Attack, Stroke, and Kidney Failure, leading to their withdrawal from human use.
- Uncovering the dangers of Cox-2 use, leading to its withdrawal from human use.[3]
References
edit- ^ Mintz, Howard; Group, Bay Area News (December 22, 2008). "Santa Clara County jury orders Pfizer to pay $38 million in stolen trade secrets case". The Mercury News. Retrieved June 26, 2024.
- ^ II, Thomas H. Maugh (January 26, 2006). "Multiple Risks of Surgery Drug Seen". Los Angeles Times. Retrieved June 26, 2024.
- ^ a b c "RESEARCHER BEAT PFIZER, THEN LOST TO IT". Tampa Bay Times. Retrieved June 26, 2024.
- ^ "Pfizer Hit With $38 Million Jury Verdict in IP Case". Law.com. Retrieved June 26, 2024.
- ^ Stern, Andrew (August 10, 2007). "Drug to slow bleeding leads to more deaths: study". Reuters.
- ^ "Aspirin beneficial after CABG". Medscape. Retrieved June 26, 2024.
- ^ "Efficacy of Beta-Blockade and Aspirin for Secondary Prevention Following Cardiac Bypass Surgery". AHA Journals. October 31, 2024. doi:10.1161/circ.114.suppl_18.II_475-c (inactive June 27, 2024).
{{cite web}}: CS1 maint: DOI inactive as of June 2024 (link)