The Daf-9 gene encodes a cytochrome p450 enzyme catalysis the generation of dafachronic acid (a steroid hormone) in the worm Caenorhabditis elegans,[1] with the CYP Symbol CYP22A1 (Cytochrome P450, family 22, member A1). After generation, dafachronic acid will binding it's nuclear receptor Daf-12 and has been implicated by Cynthia Kenyon and colleagues related to the formation of Dauer larva.[2]
| Cytochrome P450 daf-9 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | daf-9 | ||||||
| Alt. symbols | CYP22A1 | ||||||
| Entrez | 180889 | ||||||
| RefSeq (mRNA) | NM_001029732.2 | ||||||
| RefSeq (Prot) | NP_001024903.1 | ||||||
| UniProt | H2KYS3 | ||||||
| Other data | |||||||
| Chromosome | X: 6.2 - 6.2 Mb | ||||||
| |||||||
References
edit- ^ Jia K, Albert PS, Riddle DL (2002). "DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity". Development. 129 (1): 221–31. doi:10.1242/dev.129.1.221. PMID 11782415.
- ^ Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993). "A C. elegans mutant that lives twice as long as wild type". Nature. 366 (6454): 461–464. Bibcode:1993Natur.366..461K. doi:10.1038/366461a0. PMID 8247153. S2CID 4332206.