DXL may refer to:
- Destination XL Group, a specialty retailer of men's apparel
- Docetaxel, a chemotherapy medication
- Domino XML, a markup language used by IBM Notes
- DOORS Extension Language, a scripting language for IBM's Rational DOORS
- Dual X-ray absorptiometry and laser, a technique for calculating bone mineral density
This disambiguation page lists articles associated with the title DXL.
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