Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene.[5][6]

DUSP12
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDUSP12, DUSP1, YVH1, dual specificity phosphatase 12
External IDsOMIM: 604835; MGI: 1890614; HomoloGene: 5238; GeneCards: DUSP12; OMA:DUSP12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007240

NM_023173

RefSeq (protein)

NP_009171

NP_075662
NP_001343414
NP_001343415

Location (UCSC)Chr 1: 161.75 – 161.76 MbChr 1: 170.87 – 170.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.

Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000081721Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026659Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Muda M, Manning ER, Orth K, Dixon JE (Sep 1999). "Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function". J Biol Chem. 274 (34): 23991–5. doi:10.1074/jbc.274.34.23991. PMID 10446167.
  6. ^ a b "Entrez Gene: DUSP12 dual specificity phosphatase 12".

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: Q9UNI6 (Dual specificity protein phosphatase 12) at the PDBe-KB.