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DIS3L

  (Redirected from DIS3L1)

DIS3-like exonuclease 1 (Dis3L1 or Dis3L) is an enzyme that in humans is encoded by the DIS3L gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the cytoplasm of eukaryotic cells.[5][6]

DIS3L
Identifiers
AliasesDIS3L, DIS3L1, DIS3 like exosome 3'-5' exoribonuclease
External IDsOMIM: 614183 MGI: 2143272 HomoloGene: 15797 GeneCards: DIS3L
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for DIS3L
Genomic location for DIS3L
Band15q22.31Start66,293,217 bp[1]
End66,333,898 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001001295
NM_001177784
NM_172519

RefSeq (protein)

NP_001001295
NP_001171255
NP_766107

Location (UCSC)Chr 15: 66.29 – 66.33 MbChr 9: 64.31 – 64.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166938 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032396 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Staals RH, Bronkhorst AW, Schilders G, Slomovic S, Schuster G, Heck AJ, Raijmakers R, Pruijn GJ (July 2010). "Dis3-like 1: a novel exoribonuclease associated with the human exosome". EMBO J. 29 (14): 2358–67. doi:10.1038/emboj.2010.122. PMC 2910272. PMID 20531389.
  6. ^ Tomecki R, Kristiansen MS, Lykke-Andersen S, Chlebowski A, Larsen KM, Szczesny RJ, Drazkowska K, Pastula A, Andersen JS, Stepien PP, Dziembowski A, Jensen TH (July 2010). "The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L". EMBO J. 29 (14): 2342–57. doi:10.1038/emboj.2010.121. PMC 2910271. PMID 20531386.