Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 is an enzyme that in humans is encoded by the DHX16 gene .[ 5] [ 6]
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases . They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis , spermatogenesis , and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked.[ 6]
^ a b c ENSG00000206486, ENSG00000233418, ENSG00000231377, ENSG00000227222, ENSG00000204560, ENSG00000233049, ENSG00000226171 GRCh38: Ensembl release 89: ENSG00000233561, ENSG00000206486, ENSG00000233418, ENSG00000231377, ENSG00000227222, ENSG00000204560, ENSG00000233049, ENSG00000226171 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024422 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Imamura O, Saiki K, Tani T, Ohshima Y, Sugawara M, Furuichi Y (Jun 1998). "Cloning and characterization of a human DEAH-box RNA helicase, a functional homolog of fission yeast Cdc28/Prp8" . Nucleic Acids Res . 26 (9): 2063–8. doi :10.1093/nar/26.9.2063 . PMC 147520 PMID 9547260 . ^ a b "Entrez Gene: DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16" .
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