DDX10

Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10 gene.

DDX10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PL3
Identifiers
Aliases	DDX10, HRH-J8, DEAD-box helicase 10, Dbp4
External IDs	OMIM: 601235; MGI: 1924841; HomoloGene: 20922; GeneCards: DDX10; OMA:DDX10 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q22.3 Start 108,665,058 bp End 108,940,999 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.3 Start 53,009,935 bp End 53,159,353 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve testicle Achilles tendon right testis left testis gonad ganglionic eminence ventricular zone kidney tubule left uterine tube Top expressed in tail of embryo otic placode saccule genital tubercle Gonadal ridge epiblast primitive streak otic vesicle hair follicle maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA helicase activity nucleotide binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding Cellular component nucleolus cytoplasm Biological process RNA secondary structure unwinding anterior head development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1662 77591 Ensembl ENSG00000178105 ENSMUSG00000053289 UniProt Q13206 Q80Y44 RefSeq (mRNA) NM_004398 NM_029936 RefSeq (protein) NP_004389 NP_084212 Location (UCSC) Chr 11: 108.67 – 108.94 Mb Chr 9: 53.01 – 53.16 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang SC, Lien HC, Xia W, et al. (2004). "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2". Cancer Cell. 6 (3): 251–61. doi:10.1016/j.ccr.2004.07.012. PMID 15380516.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Nakao K, Nishino M, Takeuchi K, et al. (2000). "Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome". Intern. Med. 39 (5): 412–5. doi:10.2169/internalmedicine.39.412. PMID 10830185.
• Zuber J, Tchernitsa OI, Hinzmann B, et al. (2000). "A genome-wide survey of RAS transformation targets". Nat. Genet. 24 (2): 144–52. doi:10.1038/72799. PMID 10655059. S2CID 21887748.
• Ikeda T, Ikeda K, Sasaki K, et al. (1999). "The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts". Int. J. Hematol. 69 (3): 160–4. PMID 10222653.
• Liang WQ, Clark JA, Fournier MJ (1997). "The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein". Mol. Cell. Biol. 17 (7): 4124–32. doi:10.1128/mcb.17.7.4124. PMC 232266. PMID 9199348.
• Arai Y, Hosoda F, Kobayashi H, et al. (1997). "The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10". Blood. 89 (11): 3936–44. doi:10.1182/blood.V89.11.3936. PMID 9166830.