dATP(dGTP)—DNA purinetransferase
(Redirected from DATP(dGTP):depurinated-DNA purine transferase)
dATP(dGTP)—DNA purinetransferase (EC 2.6.99.1) is an enzyme with systematic name dATP(dGTP):depurinated-DNA purine transferase.[1][2] This enzyme catalyses the following chemical reaction
| dATP(dGTP)—DNA purinetransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.6.99.1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (1) dATP + depurinated DNA deoxyribose triphosphate + DNA
- (2) dGTP + depurinated DNA deoxyribose triphosphate + DNA
The purine residue is transferred on to the apurinic site forming a normal glycosylic bond.
References
edit- ^ Deutsch WA, Linn S (January 1979). "DNA binding activity from cultured human fibrolasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites". Proceedings of the National Academy of Sciences of the United States of America. 76 (1): 141–4. Bibcode:1979PNAS...76..141D. doi:10.1073/pnas.76.1.141. PMC 382892. PMID 218192.
- ^ Livneh Z, Elad D, Sperling J (March 1979). "Enzymatic insertion of purine bases into depurinated DNA in vitro". Proceedings of the National Academy of Sciences of the United States of America. 76 (3): 1089–93. Bibcode:1979PNAS...76.1089L. doi:10.1073/pnas.76.3.1089. PMC 383194. PMID 375225.
External links
edit- DATP(dGTP)---DNA+purinetransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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