D99 may refer to:
- HMS Duncan (D99)
- HMS Durban (D99)
- Greek destroyer Kountouriotis (D99)
- an ECO code for the Grünfeld Defence in chess
- slogan of XHJD-FM radio, a CHR radio station from Monterrey, Nuevo León
- D99 (New York City bus), a New York City Bus route in Brooklyn
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