D59 or D-59 may be:
- HMAS Anzac (D59), a Battle class destroyer of the Royal Australian Navy
- HMCS Skeena (D59), an A class destroyer of the Royal Canadian Navy
- Queen's Gambit Declined, in the classification system of the Encyclopaedia of Chess Openings
- D59 road (Croatia), a state road in Croatia
- HMS Ceres (D59)
- D59 (Antarctica), a field camp in Antarctica
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