D0 may refer to:
- d0, the d electron count of a transition metal complex
- D0 meson
- D0 experiment, at the Tevatron collider at Fermilab, in Batavia, Illinois, US
- D0 motorway (Czech Republic), the partially complete outer ring road of Prague
- Dangling bond, in chemistry
- DHL Air Limited (IATA code)
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