Gap junction alpha-4 protein, also known as Connexin-37 or Cx37, is a protein that in humans is encoded by the GJA4 gene.[5][6][7] This protein, like other Connexin proteins, forms connections between cells known as gap junctions. Connexin 37 can be found in many tissues including the ovary,[8] heart,[9] and kidney.[10]

GJA4
Identifiers
AliasesGJA4, CX37, gap junction protein alpha 4
External IDsOMIM: 121012; MGI: 95715; HomoloGene: 1556; GeneCards: GJA4; OMA:GJA4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002060

NM_008120

RefSeq (protein)

NP_002051

NP_032146

Location (UCSC)Chr 1: 34.79 – 34.8 MbChr 4: 127.21 – 127.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187513Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050234Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Richard G, Smith LE, Bailey RA, Itin P, Hohl D, Epstein EH, DiGiovanna JJ, Compton JG, Bale SJ (December 1998). "Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis". Nature Genetics. 20 (4): 366–9. doi:10.1038/3840. PMID 9843209. S2CID 841727.
  6. ^ Reed KE, Westphale EM, Larson DM, Wang HZ, Veenstra RD, Beyer EC (March 1993). "Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein". The Journal of Clinical Investigation. 91 (3): 997–1004. doi:10.1172/JCI116321. PMC 288052. PMID 7680674.
  7. ^ "Entrez Gene: GJA4 gap junction protein, alpha 4, 37kDa".
  8. ^ Winterhager E, Kidder GM (May 2015). Gap junction connexins in female reproductive organs: implications for women's reproductive health. Vol. 21. pp. 340–52. doi:10.1093/humupd/dmv007. PMID 25667189. {{cite book}}: |journal= ignored (help)
  9. ^ Duffy HS, Fort AG, Spray DC (2006). "Cardiac connexins: genes to nexus". Cardiovascular Gap Junctions. Advances in Cardiology. Vol. 42. pp. 1–17. doi:10.1159/000092550. ISBN 978-3-8055-8077-9. PMID 16646581.
  10. ^ Hanner F, Sorensen CM, Holstein-Rathlou NH, Peti-Peterdi J (May 2010). "Connexins and the kidney". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 298 (5): R1143–55. doi:10.1152/ajpregu.00808.2009. PMC 2867516. PMID 20164205.

Further reading

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