Creuse is a département in central France.
Creuse may also refer to:
- Creuse, Somme, a commune of the Somme département, France
- Creuse (river), a river in western France
- La Creuse, a commune in the Haute-Saône department
- Petite Creuse, a river in Allier and Creuse departments, France
- Creuse River (Petite rivière du Chêne), a river in Quebec, Canada
People with the surname
edit- Auguste de Creuse (1806–1839), French portrait painter