The cough reflex has both sensory (afferent) mainly via the vagus nerve and motor (efferent) components. Pulmonary irritant receptors (cough receptors) in the epithelium of the respiratory tract are sensitive to both mechanical and chemical stimuli. The bronchi and trachea are so sensitive to light touch that slight amounts of foreign matter or other causes of irritation initiate the cough reflex. The larynx and carina are especially sensitive. Terminal bronchioles and even the alveoli are sensitive to chemical stimuli such as sulfur dioxide gas or chlorine gas. Rapidly moving air usually carries with it any foreign matter that is present in the bronchi or trachea. Stimulation of the cough receptors by dust or other foreign particles produces a cough, which is necessary to remove the foreign material from the respiratory tract before it reaches the lungs.
The cough receptors or rapidly adapting irritant receptors are located mainly on the posterior wall of the trachea, pharynx, and at the carina of trachea, the point where the trachea branches into the main bronchi. The receptors are less abundant in the distal airways, and absent beyond the respiratory bronchioles. When triggered, impulses travel via the internal laryngeal nerve, a branch of the superior laryngeal nerve which stems from the vagus nerve (CN X), to the medulla of the brain. This is the afferent neural pathway. Unlike other areas responsible for involuntary actions like swallowing, there is no definitive area that has been identified as the cough center in the brain.
The efferent neural pathway then follows, with relevant signals transmitted back from the cerebral cortex and medulla via the vagus and superior laryngeal nerves to the glottis, external intercostals, diaphragm, and other major inspiratory and expiratory muscles. The mechanism of a cough is as follows:
- Diaphragm (innervated by phrenic nerve) and external intercostal muscles (innervated by segmental intercostal nerves) contract, creating a negative pressure around the lung.
- Air rushes into the lungs in order to equalise the pressure.
- The glottis closes (muscles innervated by recurrent laryngeal nerve) and the vocal cords contract to shut the larynx.
- The abdominal muscles contract to accentuate the action of the relaxing diaphragm; simultaneously, the other expiratory muscles contract. These actions increase the pressure of air within the lungs.
- The vocal cords relax and the glottis opens, releasing air at over 100 mph.
- The bronchi and non-cartilaginous portions of the trachea collapse to form slits through which the air is forced, which clears out any irritants attached to the respiratory lining.
Stimulation of the auricular branch of the vagus nerve supplying the ear may also elicit a cough. This is known as Arnold's reflex. Respiratory muscle weakness, tracheostomy, or vocal cord pathology (including paralysis or anesthesia) may prevent effective clearing of the airways.
The reflex is impaired in the person whose abdominals and respiratory muscles are weak. This problem can be caused by disease condition that lead to muscle weakness or paralysis, by prolonged inactivity, or as outcome of surgery involving these muscles. Bed rest interferes with the expansion of the chest and limits the amount of air that can be taken into the lungs in preparation for coughing, making the cough weak and ineffective. This reflex may also be impaired by damage to the internal branch of the superior laryngeal nerve which relays the afferent branch of the reflex arc. This nerve is most commonly damaged by swallowing a foreign object, such as a chicken bone, resulting in it being lodged in the piriform recess (in the laryngopharynx) or by surgical removal of said object.
- Hall, John (2011). Guyton and Hall Textbook of Medical Physiology with Student Consult Online Access (12th ed.). Philadelphia: Elsevier Saunders. ISBN 978-1-4160-4574-8.
- Hegland, K. W.; Bolser, D. C.; Davenport, P. W. (2012). "Volitional control of reflex cough". Journal of Applied Physiology. 113: 39. doi:10.1152/japplphysiol.01299.2011. PMC 3774289.
- Cough Reflex: http://www.healthhype.com/cough-reflex-physiology-process-ear-cough-reflexes.html
- Ganong WF, "Chapter 36. Regulation of Respiration" (Chapter). Ganong WF: Review of Medical Physiology, 22nd Edition: https://web.archive.org/web/20071221162754/http://www.accessmedicine.com/content.aspx?aID=706628