Charles Otis may refer to:
- Charles Otis (fencer) (1906–1970), Canadian fencer
- Charles Otis (businessman) (1872–1944), financial publisher in New York and New England
- Charles A. Otis (1827–1905), businessman and mayor of Cleveland
- Charles Pomeroy Otis (1840–1888), American educator and author
This disambiguation page lists articles about people with the same name.
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