Charles Grayson could refer to:
- Charles Grayson (writer) (1903-1973), American screenwriter and novelist
- Charles E. Grayson (1910-2009), American radiologist and archer
- Charles F. Grayson, alias of Moody Merrill (1836–1903), American politician, businessman, and fugitive
- Trey Grayson (Charles Merwin Grayson III) (born 1972), American politician
This disambiguation page lists articles about people with the same name.
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