Charles Clark Gonzaga may refer to:
- Carlo Gonzaga of Milan (died 1456), Lord of Sabbioneta
- Carlo Gonzaga (condottiero) (1525–1566), Italian military leader
- Carlo I Gonzaga, or Charles I, Duke of Mantua (1580–1637), Lord of Montferrat, Duke of Nevers, Duke of Mayenne
- Charles II Gonzaga, (1609–1631), son of Carlo I, married to Maria Gonzaga
- Charles III, Duke of Mantua and Montferrat (1629–1665), son of Charles II
- Charles IV, Duke of Mantua and Montferrat (1652–1708), son of Charles III, last ruler of Mantua
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