M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.[5]

CDC25C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDC25C, CDC25, PPP1R60, cell division cycle 25C
External IDsOMIM: 157680; MGI: 88350; HomoloGene: 1356; GeneCards: CDC25C; OMA:CDC25C - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_009860

RefSeq (protein)

NP_033990

Location (UCSC)Chr 5: 138.29 – 138.34 MbChr 18: 34.87 – 34.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.[6]

Interactions

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CDC25C has been shown to interact with MAPK14,[7] CHEK1,[8] PCNA,[9] PIN1,[10][11][12] PLK3[13] and NEDD4.[12]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158402Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044201Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gould KL, Moreno S, Tonks NK, Nurse P (Feb 1991). "Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase". Science. 250 (4987): 1573–6. Bibcode:1990Sci...250.1573G. doi:10.1126/science.1703321. PMID 1703321. S2CID 25037148.
  6. ^ "Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe)".
  7. ^ Bulavin DV, Higashimoto Y, Popoff I J, Gaarde W A, Basrur V, Potapova O, Appella E, Fornace A J (May 2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature. 411 (6833). England: 102–7. doi:10.1038/35075107. ISSN 0028-0836. PMID 11333986. S2CID 4410763.
  8. ^ Sanchez Y, Wong C, Thoma R S, Richman R, Wu Z, Piwnica-Worms H, Elledge S J (Sep 1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science. 277 (5331). UNITED STATES: 1497–501. doi:10.1126/science.277.5331.1497. ISSN 0036-8075. PMID 9278511.
  9. ^ Kawabe T, Suganuma Masashi, Ando Tomoaki, Kimura Mayumi, Hori Haruna, Okamoto Takashi (Mar 2002). "Cdc25C interacts with PCNA at G2/M transition". Oncogene. 21 (11). England: 1717–26. doi:10.1038/sj.onc.1205229. ISSN 0950-9232. PMID 11896603.
  10. ^ Shen M, Stukenberg P T, Kirschner M W, Lu K P (Mar 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. 12 (5). UNITED STATES: 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589. PMID 9499405.
  11. ^ Goldstrohm AC, Albrecht T R, Suñé C, Bedford M T, Garcia-Blanco M A (Nov 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22). United States: 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. ISSN 0270-7306. PMC 99933. PMID 11604498.
  12. ^ a b Lu PJ, Zhou X Z, Shen M, Lu K P (Feb 1999). "Function of WW domains as phosphoserine- or phosphothreonine-binding modules". Science. 283 (5406). UNITED STATES: 1325–8. Bibcode:1999Sci...283.1325L. doi:10.1126/science.283.5406.1325. ISSN 0036-8075. PMID 10037602.
  13. ^ Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. 18 (44). ENGLAND: 6029–36. doi:10.1038/sj.onc.1202983. ISSN 0950-9232. PMID 10557092.

Further reading

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