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Amezcua is the son of Don Oscar Amezcua, who was a mariachi musician, part of Mariachi Vargas de Tecalitlán. Carlos Amezcua was raised in Barrio Logan in San Diego, California. He began his undergraduate studies at Brigham Young University where he joined The Church of Jesus Christ of Latter-day Saints. He served as an LDS missionary in the Guatemala-El Salvador Mission.
Amezcua, formerly with KTLA, was the anchor of the KTLA Morning News in the Los Angeles from 1991 to 2007. Prior to this, he was a reporter in San Diego, Denver and Portland, Oregon and a network correspondent for CBS News and also reported for "NBC Nightly News," CNN and HBO’s "America Undercover."
Amezcua, a Southern California native,studied at BYU and San Diego State University.