Carlisle High School may refer to:
- Carlisle High School (Carlisle, Arkansas)
- Carlisle High School (Carlisle, Iowa)
- Carlisle High School (Carlisle, Ohio)
- Carlisle High School (Carlisle, Pennsylvania)
- Carlisle High School (Price, Texas)
- Carlisle and County High School for Girls, a former girls grammar school in Carlisle (England), now called Richard Rose Central Academy
- Carlisle County High School (Bardwell, Kentucky)
- Concord-Carlisle High School (Concord, Massachusetts)
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