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Cardiac neural crest complex

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The cardiac neural crest complex is a form of neural crest.[1]

Cardiac neural crest complex
Latincomplexus cristae neuralis cardiacus
Anatomical terminology


The cardiac neural crest develops from the dorsal neural tube.[2] It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart.

Notch2 plays an important role in development.[3]



  1. ^ "The Neural Crest". Retrieved 2009-05-31.
  2. ^ Sun X, Zhang R, Lin X, Xu X (April 2008). "Wnt3a regulates the development of cardiac neural crest cells by modulating expression of cysteine-rich intestinal protein 2 in rhombomere 6". Circ. Res. 102 (7): 831–9. doi:10.1161/CIRCRESAHA.107.166488. PMID 18292601.
  3. ^ Varadkar P, Kraman M, Despres D, Ma G, Lozier J, McCright B (April 2008). "Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells". Dev. Dyn. 237 (4): 1144–52. doi:10.1002/dvdy.21502. PMID 18330927.
  4. ^ Jiang X, Rowitch DH, Soriano P, McMahon AP, Sucov HM (April 2000). "Fate of the mammalian cardiac neural crest". Development. 127 (8): 1607–16. PMID 10725237.