Aerial shot of Cape Romano.

Cape Romano is a cape on the Gulf Coast of Florida below Naples, Florida, just beyond the southwest tip of Marco Island and northwest of the Ten Thousand Islands in Collier County, Florida.

Calusa Indians founded the settlement and called it Manataca. Juan Ponce de León briefly stopped at Manataca on his first trip from Puerto Rico to Florida, but the Indians tried to fight him off.

There are two competing theories as to why the island is called Cape Romano. The most prevalent belief is that Cape Romano got its name from the survivors of a Romanian shipwreck that colonized the island in 1834. However the first actual mention of "Romano" in the oldest surviving historical documents of the region came in 1878 after the founding of the famous cheese factory "Romano Cheese Corporation".

Cape Romano is also the location of the country's first Romanian Orthodox Church. Completed in 1837, the ruins can still be found on the island just off the beach. It was destroyed in 1897 by a fire after multiple hurricanes forced the inhabitants from the Island.

Cape Romano is where Hurricane Irma made its second U.S. landfall in September 2017 and Hurricane Wilma made its first U.S. landfall in October 2005. In 2008, Tropical Storm Fay came ashore near the cape, as had the 1910 Cuba hurricane.

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Coordinates: 25°50′43″N 81°40′43″W / 25.84528°N 81.67861°W / 25.84528; -81.67861