Cannonball Express may refer to:
- Cannonball Express, a steam locomotive operated by Casey Jones
- Cannonball Express (film), a 1932 film produced by Sono Art-World Wide Pictures
- Cannonball Express, a Friday afternoon train on the Long Island Rail Road departing from Penn Station and running non-stop to the Hamptons
- Cannonball Express, a planet in the fictional Known Space universe created by Larry Niven
- Cannonball Express, a roller coaster located at Pleasurewood Hills, Corton, Near Lowestoft, Suffolk
- Dreamworld Express, a narrow gauge railway located at the Dreamworld theme park
- The Cannonball Express, a song by jazz singer Peggy Lee
- The Cannonball Express, a band formed by the American electric blues guitarist, vocalist and songwriter, Toronzo Cannon
- The Cannonball Christmas Express, a special excursion train operated by the Tavares, Eustis & Gulf Railroad
- Wabash Cannon Ball, an express train line on the Wabash Railroad which ran from the late 1800s to the early 1900s, and again from 1950 to 1971
- Wabash Cannonball, an American folk song about a fictional Wabash Cannonball Express train
- Wabash Cannonball Express Railroad, a miniature train ride at the Indiana Beach amusement park