Cathepsin H

(Redirected from CTSH (gene))

Cathepsin H is a protein that in humans is encoded by the CTSH gene.[5][6]

CTSH
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTSH, ACC-4, ACC-5, CPSB, minichain, ACC4, ACC5, cathepsin H
External IDsOMIM: 116820; MGI: 107285; HomoloGene: 36159; GeneCards: CTSH; OMA:CTSH - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004390
NM_148979
NM_001319137

NM_007801
NM_001312649

RefSeq (protein)

NP_001306066
NP_004381

NP_001299578
NP_031827

Location (UCSC)Chr 15: 78.92 – 78.95 MbChr 9: 89.94 – 89.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a cysteine cathepsin, a lysosomal cysteine protease important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103811Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032359Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fuchs R, Machleidt W, Gassen HG (Feb 1989). "Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H". Biol Chem Hoppe-Seyler. 369 (6): 469–75. doi:10.1515/bchm3.1988.369.1.469. PMID 2849458.
  6. ^ a b "Entrez Gene: CTSH cathepsin H".

Further reading

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  • The MEROPS online database for peptidases and their inhibitors: C01.040