Transcriptional repressor CTCFL also known as BORIS (Brother of Regulator of Imprinted Sites) is a protein that in humans is encoded by the CTCFL gene.[4]

CTCFL
Identifiers
AliasesCTCFL, BORIS, CT27, CTCF-T, HMGB1L1, dJ579F20.2, CCCTC-binding factor like
External IDsOMIM: 607022; MGI: 3652571; HomoloGene: 46476; GeneCards: CTCFL; OMA:CTCFL - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001081387
NM_001355185

RefSeq (protein)

NP_001074856
NP_001342114

Location (UCSC)n/aChr 2: 172.94 – 172.96 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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CCCTC-binding factor (CTCF), an 11-zinc finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. Transcriptional repressor CTCFL (this protein) is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and CTCFL are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation.[4]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070495Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b "Entrez Gene: CTCFL CCCTC-binding factor (zinc finger protein)-like".

Further reading

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