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Prolycopene isomerase

  (Redirected from CRTISO)

Prolycopene isomerase (EC, CRTISO, carotene cis-trans isomerase, ZEBRA2 (gene), carotene isomerase, carotenoid isomerase) is an enzyme with systematic name 7,9,7',9'-tetracis-lycopene cis-trans-isomerase.[1][2][3][4] This enzyme catalyses the following chemical reaction

Prolycopene isomerase
EC number5.2.1.13
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
7,9,7',9'-tetracis-lycopene all-trans-lycopene

This enzyme is involved in carotenoid biosynthesis.


  1. ^ Yu Q, Ghisla S, Hirschberg J, Mann V, Beyer P (March 2011). "Plant carotene cis-trans isomerase CRTISO: a new member of the FAD(RED)-dependent flavoproteins catalyzing non-redox reactions". The Journal of Biological Chemistry. 286 (10): 8666–76. doi:10.1074/jbc.m110.208017. PMC 3048748. PMID 21209101.
  2. ^ Li Q, Farre G, Naqvi S, Breitenbach J, Sanahuja G, Bai C, Sandmann G, Capell T, Christou P, Zhu C (December 2010). "Cloning and functional characterization of the maize carotenoid isomerase and β-carotene hydroxylase genes and their regulation during endosperm maturation". Transgenic Research. 19 (6): 1053–68. doi:10.1007/s11248-010-9381-x. PMID 20221689.
  3. ^ Isaacson T, Ronen G, Zamir D, Hirschberg J (February 2002). "Cloning of tangerine from tomato reveals a carotenoid isomerase essential for the production of beta-carotene and xanthophylls in plants". The Plant Cell. 14 (2): 333–42. doi:10.1105/tpc.010303. PMC 152916. PMID 11884678.
  4. ^ Chai C, Fang J, Liu Y, Tong H, Gong Y, Wang Y, Liu M, Wang Y, Qian Q, Cheng Z, Chu C (February 2011). "ZEBRA2, encoding a carotenoid isomerase, is involved in photoprotection in rice". Plant Molecular Biology. 75 (3): 211–21. doi:10.1007/s11103-010-9719-z. PMID 21161331.

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