Crumbs protein homolog 3 is a protein that in humans is encoded by the CRB3 gene .[ 5]
This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[ 5]
Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A (Jul 2002). "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells" . The Journal of Biological Chemistry . 277 (28): 25408–15. doi :10.1074/jbc.M202196200 PMID 11964389 . Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B (Jan 2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)". Gene . 302 (1–2): 21–9. doi :10.1016/S0378111902010843 . PMID 12527193 . Roh MH, Fan S, Liu CJ, Margolis B (Jul 2003). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells" . Journal of Cell Science . 116 (Pt 14): 2895–906. doi :10.1242/jcs.00500 PMID 12771187 . Lemmers C, Michel D, Lane-Guermonprez L, Delgrossi MH, Médina E, Arsanto JP, Le Bivic A (Mar 2004). "CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells" . Molecular Biology of the Cell . 15 (3): 1324–33. doi :10.1091/mbc.E03-04-0235 . PMC 363137 PMID 14718572 . Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology . 22 (6): 707–16. doi :10.1038/nbt971 . PMID 15146197 . S2CID 27764390 . Fogg VC, Liu CJ, Margolis B (Jul 2005). "Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells" . Journal of Cell Science . 118 (Pt 13): 2859–69. doi :10.1242/jcs.02412 PMID 15976445 . Fan S, Fogg V, Wang Q, Chen XW, Liu CJ, Margolis B (Jul 2007). "A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions" . The Journal of Cell Biology . 178 (3): 387–98. doi :10.1083/jcb.200609096 . PMC 2064851 PMID 17646395 .
